Navigating the Intersections Between Animal Care and Use and Human Subjects Oversight: Mind the Gap
For many institutions, the review and consideration of animal care and use protocols and human subjects research are siloed. With little communication or interaction between the two review processes, gaps in considerations for appropriate protections for animals and humans arise when research protocols overlap these two spheres. More generally, there are often situations where oversight considerations fall into a gray area where there are broad implications for research animals, human subjects, and communities.
Recognizing the interconnection among people, animals, plants, and their shared environment, One Health
is a collaborative, multisectoral, and transdisciplinary initiative with the goal of achieving optimal health outcomes. One Health
is not new, but it has become more important, especially over the last year, because of increased recognition of interactions among people, animals, plants, and the environment and the health impacts of those interactions.
This session will address the intersection (and gaps!) between IACUC and IRB oversight, and will provide examples to illustrate ways these intersections and gaps can be managed, including through the use of a One Health
- Define the scope of IACUC oversight and the role the IACUC may play as part of a One Health approach.
- Define the scope of IRB oversight and the role the IRB may play as part of a One Health approach.
- Discuss where the regulations intersect and where there may be ethical gaps.
- Provide and discuss illustrative case studies:
- Example that involves human subjects and animals, where the animal use is not within the scope of IACUC, but for which there are ethical concerns regarding animals
- Example that involves animal use within the scope of IACUC and human participants, where the humans are not “subjects,” but may be put at risk of harm
- Example where both apply and everything works out well
- Example where both IACUC and IRB oversight apply, but where the respective requirements are contradictory