Several events, including recent revisions and newly proposed updates to federal regulations as well as an increase in virtual interactions, call for a moment to reflect on the state of informed consent for research with human subjects. For example, the COVID pandemic required research teams to use electronic informed consent forms and virtual communication processes to continue running their studies. Use of electronic formats leverages technology that can enhance research subjects’ understanding of the study in which they are being asked to participate, and mimic how people primarily obtain information (i.e., via the internet). Moreover, the revisions to the Common Rule and proposed updates to the FDA regulations argue for a shift in the traditional presentation of information in the consent process and documents.