Artificial intelligence (AI) is transforming research across disciplines and around the world—raising urgent ethical questions that challenge traditional oversight models. This timely PRIM&R symposium convenes leading voices in the field to examine the far-reaching impact of AI technologies on research ethics and governance. Join experts for a thought-provoking exploration of AI’s role in shaping study design, data integrity, human subject protections, and decision-making. From biomedical research to behavioral and data science, AI is creating new possibilities—and new risks—that demand close scrutiny and thoughtful response. Designed for professionals in research oversight, compliance, and policy, this program will analyze emerging dilemmas such as algorithmic bias, transparency in machine learning models, and the ethical implications of data automation. Presenters will assess how current regulatory frameworks are being tested by these developments and offer practical strategies for navigating this evolving terrain. With a global research community in mind, the symposium will explore challenges that resonate across institutional types, sectors, and regions—equipping participants with insights they can apply in academic, nonprofit, industry, or government settings.