Many IACUC administrators, members, and staff struggle with protocol questions and what the IACUC should consider in reviewing protocols. During this session, speakers and attendees will work through case studies on protocol review issues and discuss possible ways to handle these complex situations. Before attending this session, attendees should have a sound working knowledge of the IACUC and the regulations that provide guidance. Important to the session are well-versed IACUC administrators who can share their experiences with protocol challenges.