Research security requirements are rapidly reshaping institutional compliance landscapes, with direct implications for IRB and IACUC review processes. This Flash Learn provides IRB and IACUC professionals with a targeted, practice-oriented overview of research security and foreign influence requirements emerging from NSPM-33, the CHIPS and Science Act, and related federal mandates. Attendees will learn how these requirements intersect with protocol review, informed consent, data protections, animal research oversight, and investigator disclosures. Through brief examples and “review-room ready” strategies, attendees will leave with concrete approaches for identifying research security red flags, knowing when to escalate concerns, and collaborating effectively with institutional research security leadership—without overstepping committee scope.